Adenylate Cyclase-Activating Polypeptide in Rodents
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چکیده
14 Abstract Administration of the long form (38 amino acids) 15 of pituitary adenylate cyclase-activating polypeptide 16 (PACAP38) into the central nervous system causes hyperther17 mia, suggesting that PACAP38 plays a role in the regulation of 18 deep body temperature (Tb). In this study, we investigated the 19 thermoregulatory role of PACAP38 in details. First, we in20 fused PACAP38 intracerebroventricularly to rats and mea21 sured their Tb and autonomic thermoeffector responses. We 22 found that central PACAP38 infusion caused dose-dependent 23 hyperthermia, which was brought about by increased thermo24 genesis and tail skin vasoconstriction. Compared to intra25 cerebroventricular administration, systemic (intravenous) in26 fusion of the same dose of PACAP38 caused significantly 27 smaller hyperthermia, indicating a central site of action. We 28 then investigated the thermoregulatory phenotype of mice 29 lacking the Pacap gene (Pacap). Freely moving Pacap 30 mice had higher locomotor activity throughout the day and 31 elevated deep Tb during the light phase. When the Pacap −/−
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تاریخ انتشار 2014